Total synthesis of actinophenanthroline

Total synthesis of actinophenanthroline A, a marine actinomycete within the family ofStreptomycetaceae (strain CNQ-149) is reported. Both the racemic and enantiopure actinophenanthrolineA have been synthesized with good overall yields. Highlight of the synthesis contains the classical andeconomical double Doebner–Miller reaction to access the 1,7-phenanthroline core followed by a modifiedEDCI coupling.

Title: Total synthesis of actinophenanthroline A via double Doebner–Millerreaction

Journal: Tetrahedron Letters 57 (2016) 4009–4011

http://dx.doi.org/10.1016/j.tetlet.2016.06.045